Primerlab

Primer sanity checker

Input

Primer Sequences

Only A, C, G, T allowed. Spaces and line breaks will be ignored.

Only A, C, G, T allowed. Spaces and line breaks will be ignored.

PCR Settings (Optional)

These values are used for simple Tm estimation and an approximate PCR mix. You can leave defaults if you’re not sure.

Results

Summary

No analysis yet

    Primer Metrics

    Metric Forward Reverse
    Length (nt)
    GC content (%)
    Tm (°C)
    3'-end GC clamp
    Basic validity

    Secondary Structure & Dimers

    Self-dimers

      Primer–primer dimers

        Other flags

          Suggested Annealing Temperature

          Recommended Ta:

          Gradient suggestion:

          Rule-of-thumb: Ta ≈ Tmlower − 3–5 °C. This is a simplified estimate for quick planning.

          PCR Mix (Suggested)

          Based on your reaction volume and primer concentrations. Always adjust for your specific polymerase / protocol.

          Component Stock Final Volume (µL)